Scalable Assays for Unbiased Analysis of Neurobiological Function (R01)

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Purpose. This Funding Opportunity Announcement (FOA) encourages research grant applications from institutions/organizations to develop novel, robust analytical platforms using in vitro assays to reveal changes in neuronal and/or glial function. The goal is to adapt state-of-the-art measures of basic cellular processes or molecular events that are key mediators of brain function with the intent to probe mechanisms and/or perturbations in an unbiased and efficient manner. The novel assay platforms would provide opportunities to measure neurobiological endpoints and build a pipeline to be used in the context of target identification and drug discovery. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism Funds Available and Anticipated Number of Awards. The NIMH intends to commit approximately $3 million total costs in FY 2011 to fund 5-10 awards and NINDS intends to commit approximately $2 million total costs in FY 2011 to fund 3-6 awards.

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