Sleep Health and Circadian Biology in HIV-Related Comorbidities (R01)

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This Funding Opportunity Announcement (FOA) invites clinical research applications to investigate HIV-associated sleep disorders in adults or children using a variety of resources (e.g., existing cohorts, sample repositories) and methodologies (cellular/molecular/genomic approaches and/or vertebrate animal models). The purpose of this FOA is to elucidate mechanisms and mediators of sleep and circadian disturbances in people living with HIV, and the consequences and influences of these disturbances on other HIV-related heart, lung and blood comorbidities. Studies should address hypotheses mechanistically connecting sleep-associated disorders in the context of HIV with molecular/cellular pathways that may be related to prevalent HIV-related cardiopulmonary and/or hematological comorbidities. This FOA requires interdisciplinary collaborations among scientists across a range of relevant disciplines including circadian biology, sleep, and HIV.

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