Structural Analyses of the Ligand-Binding Properties of Taste and Smell Receptors (R01)

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Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Deafness and Other Communication Disorders (NIDCD), encourages grant applications from institutions/organizations designed to foster innovative collaborative research to characterize the structural properties of taste and smell receptors. Additional emphasis is placed on the characterization of the interactions among odors, pheromones, and taste substances with their cognate receptors, and the identity of the critical ligand-receptor binding sites that determine sensitivity and selectivity. One aim of this FOA is to encourage collaborations among chemosensory molecular biologists and biochemists with expertise in the isolation and characterization of membrane proteins, and biophysicists familiar with crystallography, NMR and other analytical tools used in structural analyzes. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-395, that encourages applications under the Exploratory/Developmental (R21) grant mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed 5 years. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Application Research Plan Component Length: The R01 application Research Plan component of the PHS398 (Items 2-5) may not exceed 25 pages, including tables, graphs, figures, diagrams, and charts. Seehttp://grants.nih.gov/grants/funding/funding_program.htm Eligible Institutions/Organizations. Institutions/organizations listed in Section III, 1.A. are eligible to apply. Eligible Project Directors/Principal Investigators (PDs/PIs). Include Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of PDs/PIs. More than one PD/PI (i.e., multiple PDs/PIs), may be designated on the application. Number of Applications. Applicants may submit more than one application, provided that each application is scientifically distinct. Resubmissions. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). See new NIH policy on resubmission (amended) applications (NOT-OD-09-003, NOT-OD-09-016). Renewals. Applicants may submit a renewal application.

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