Structural Biology of Membrane Proteins (R01)

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Purpose. This FOA issued by NIGMS, as well as NCI, NIA, NIDCD, NIDDK, NIDA, NIEHS and NHLBI, National institutes of Health, encourages grant applications from institutions/organizations that propose to develop research and methods to enhance the rate of membrane protein structure determination and to determine specific membrane protein structures. Innovative methods for expression, oligomerization, solubilization, stabilization, purification, characterization, crystallization, isotopic labeling, and structure determination of unique and biologically significant membrane proteins by x-ray diffraction, nuclear magnetic resonance (NMR), electron microscopy, mass spectrometry, and other biophysical techniques are encouraged. Projects that will lead in the near term to determining the structures of biologically important membrane proteins are also encouraged. Responding to this FOA, rather than the regular investigator-initiated Research Project Grant (R01) FOA, will help NIH staff track interest and progress of research in this scientific area.

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