Targeting Co-dependent Molecular Pathways in Oral Cancer (U01)

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The purpose of this Funding Opportunity Announcement (FOA) is to support multi-disciplinary projects aimed at the development of new targeted and effective therapies through systematic use and leveraging of recently identified genomic abnormalities and attendant changes in gene and/or protein expression profiles in human oral cancer samples. The goal of the FOA is the identification of co-dependent survival and proliferation pathways in oral cancer cells and the elucidation of potential signaling pathways that can be targeted with combination therapy approaches. This initiative requires collaboration of multi-disciplinary research teams that include cancer biologists, computational biologists, model system specialists and/or screening assay specialists. The emphasis will be on the conceptual phase of target identification and exploration including proof-of-concept phase.

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