Technology Development for High-Throughput Structural Biology Research (R01)

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Purpose. This FOA issued by the National Institute of General Medical Sciences (NIGMS), National Institutes of Health, encourages grant applications from institutions/organizations that propose to develop novel technologies and methodologies underpinning high-throughput structural biology. Applications for new ideas and approaches for protein production and structure determination for classes of challenging proteins are appropriate. Projects related to high-throughput structure determination by X-ray crystallography and NMR, as well as projects addressing other constituent tasks of structural biology, including structural genomics, are relevant to this FOA. Applications should focus on methods development to solve challenging proteins that are not currently amenable to high-throughput structural biology. These challenging proteins include, but are not limited to, membrane proteins, small protein complexes, and proteins from human and other higher eukaryotes. Mechanism of Support. This FOA will utilize the R01 research grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-10-074, that encourages applications under the P01 mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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