The Early Detection Research Network: Clinical Validation Centers (U01)

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The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Clinical Validation Centers (CVCs), one of the four scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. The proposed CVCs will be responsible for clinical research on the validation of biomarkers. CVCs will also serve as clinical resource centers for the EDRN by participating in collaborative biomarker validation studies and collaborating with the other scientific units of the EDRN. The other three scientific components of the continuing EDRN program are: the Biomarker Developmental Laboratories (BDLs), which will be responsible for the development and characterization of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of early cancer; the Biomarker Reference Laboratories (BRLs), which will serve as Network resources for clinical and laboratory validation of biomarkers; and the Data Management and Coordinating Center (DMCC), which will support statistical and computational analyses, informatics infrastructure, study design, coordination and support of EDRN-sponsored biomarker validation studies, and the coordination of Network-wide meetings and conferences.

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