The Influence of the Microbiome on Preterm Labor and Delivery (R21)

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This funding opportunity announcement builds on the National Institute of Nursing Researchs (NINRs) previous efforts to understand the mechanisms related to preterm birth by leveraging the work performed by the National Institutes of Healths (NIHs) Human Microbiome Project (HMP). NINR seeks research to address the contribution of the microbiome to preterm labor and delivery. Preterm birth is a leading cause of neonatal mortality and morbidity, and evidence suggests that although there are multiple contributors, microorganisms may play a significant role. Research conducted as part of the HMP demonstrated that a shift in bacterial species occurs in women during the course of a pregnancy. An enhanced knowledge of the microbiome, the changes that are associated with increased risk for preterm labor and delivery, and the influence of genetic and environmental factors is needed to better address this important public health issue. Interdisciplinary collaborations that include nurse scientists in the project team are strongly encouraged. Additionally, applicants should consider engaging the resources and expertise of nearby or otherwise available Clinical and Translational Science Award grant sites (CTSAs) and/or federally funded research centers where possible.

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