The Role of Dysbiosis in Cardiovascular, Pulmonary and Hematological Complications During HIV Infection (R01)

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The purpose of this Funding Opportunity Announcement (FOA) is to invite basic research project grant applications for HIV Microbiome Centers to perform investigations on the role of HIV-induced dysbiosis and how this imbalance may induce and/or contribute to the occurrence of heart, lung, or blood (HLB) co-morbidities in HIV positive individuals. This FOA will support mechanistic studies that will use in vitro, in vivo, ex vivo, and in silico models applied to HIV research. The goal is to provide the critical basic science foundation to guide early translational approaches to understanding HIV-related HLB conditions in adults and children. This FOA also encourages multidisciplinary collaborations among scientists in a wide range of disciplines including (but not limited to), cardiology, pulmonology, hematology, immunology, '-omic' sciences, infectious disease, microbiology, biotechnology, and bioinformatics.

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