The Role of Microbial Metabolites in Cancer Prevention and Etiology (U01)

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This Funding Opportunity Announcement (FOA) encourages preclinical and clinical research that will describe the effect of microbially generated metabolites in cancer prevention/ progression and the molecular mechanisms underlying these effects: proliferative/apoptotic responses, cytokine production, inflammatory and immunomodulatory effects locally and/or distant. This FOA encourages pre-clinical and clinical studies that will describe the variability in the bacterial metabolites production and their contribution to cancer prevention/promotion among various racial and ethnic groups. Due to inconsistent responses to dietary interventions, this research is necessary to identify who might benefit from specific dietary recommend ations and who might be placed at risk. It is important to identify the factors that contribute to differences in response to foods and food components and to identify early markers that will identify those who will receive maximum benefits from dietary change. As these are complex questions this program will facilitate interdisciplinary collaborations among scientists engaged in research in cancer prevention and microbiology, nutrition, cancer cell biology, and cancer disparities. To achieve this goal all applications are encouraged to include multiple Program Director(s)/Principal Investigator(s) with expertise in cancer biology, microbiology, nutrition, analytical chemistry or genetics. Investigations may use either clinical or preclinical approaches. All awardees are expected to attend an annual meeting with NIH personnel to report new findings and coordinate the exchange of new information and methodologies with interested colleagues and to promote collaboration.

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