Tissue Chip Testing Centers: Validating Microphysiological Systems (U24)

archived

This Funding Opportunity Announcement (FOA) invites applications for Tissue Chip Testing Center(s) (TCTC) that will provide resources and infrastructure for the validation of tissue chips being developed as part of the NIH Tissue Chip (TC) Program or NIH Microphysiological Systems (MPS) Program. The MPS program supports a consortium of investigators developing accurate cellular and organ microsystems representative of human physiology for the evaluation of drug efficacy and toxicity (RFA-RM-11-022).The developed in vitro MPS platforms are representative of major organs and tissues in the human body and need to be validated for their predictive capabilities in the assessment of biomarkers, and the bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials.Validation of the tissue chips will be conducted through the TCTC that will be responsible for the testing of a select group of compounds using predefined assays and biomarkers according to pharmaceutical industry standards, and for the integration of the data into a public database.

High