Transdisciplinary Research in Energetics and Cancer (U54)

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Purpose. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) solicits applications for the centers for Transdisciplinary Research on Energetics and Cancer (TREC) in nutrition, physical activity, energy balance, obesity, and cancer. The TREC initiative (http://cancercontrol.cancer.gov/trec/) is designed to foster collaboration across multiple disciplines and encompasses projects that cover the biology, genomics, and genetics of energy balance to behavioral, socio-cultural, and environmental influences upon nutrition, physical activity, weight, energetics, and cancer risk. This initiative is open to all qualified candidates regardless of whether or not they participated in the previous issuance of the TREC Program. Applicants responding to this FOA should establish transdisciplinary research teams with the appropriate breadth of expertise. TREC has two main goals, which are: (1) to enhance knowledge of the current mechanisms underlying the association between energy balance and carcinogenesis (from cellular, animal or human models to genetics and genomics and across the cancer continuum from causation and prevention); and (2) to explore and integrate the etiology of obesity behavior and relevant health behavior theories, with broad population impact at the social-environmental and policy levels for prevention and control of obesity. Special focus on children, groups at high risk for obesity, and cancer survivors is encouraged. Mechanism of Support. This FOA will utilize the NIH Cooperative Agreement Specialized Centers (U54) funding mechanism. This FOA is accompanied by a separate limited competition U01 FOA (RFA-CA-10-501), which solicits renewal application for a TREC Coordination Center. Funds Available and Anticipated Number of Awards. For this TREC FOA, the NCI has committed $15M in total costs for FY2010 and $75M in total costs over a 5-year period. Approximately six awards are expected in connection with this FOA.

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