Understanding and Preventing Brain Tumor Dispersal (R01)

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-Purpose. The goal of this program announcement is to promote studies that 1) identify the properties of brain tumor cells that cause them to migrate; 2) determine how interaction of tumor cells with normal brain elements affects migration; and 3) translate understanding of these parameters into interventions that target invading tumor cells. -Mechanism of Support. This funding opportunity announcement (FOA) will utilize the NIH Research Project Grant (R01) mechanism and will run in parallel with an FOA of identical scientific scope, PAS-08-049, that solicits applications under the NIH Exploratory/Developmental (R21) mechanism. -Funds Available and Anticipated Number of Awards. NINDS has set aside $400,000 in total costs per year for this announcement and a parallel announcement that utilizes the R21 mechanism (see above). These funds are in addition to funds available for applications that score within the NINDS payline and depend on the overall scientific merit of the application and availability of funds throughout the duration of the announcement. NCI will consider programmatic priority and scientific merit in making funding decisions. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

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