Validation and Advanced Development of Technologies for the Study of Biological Properties of Single Cells (R33)

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This Funding Opportunity Announcement (FOA) invites applications that propose to accelerate the development of promising technologies for single cell analysis by taking them through the downstream optimization and validation process and establishing them as robust, well-characterized tools ready to transform our understanding of the biological properties of individual cells and the role those properties have in modulating the states of surrounding cells, tissues, and organs. This FOA solicits projects where proof-of-principle of the proposed technology or methodology has been established and supportive preliminary data are available. A current R21 award is not necessary. Projects should reflect the potential of single cell analysis to have a major impact on our understanding of biomedical processes, fulfill a critical unmet need by offering compelling advantages to end-users, and demonstrate the technology can be applied to multiple types of cells. It is expected that applications will have well-defined goal(s) with intermediate quantitative milestones. Projects proposing to use established technologies where the novelty resides in the biological or clinical question being pursued will be considered non-responsive and will not be reviewed.

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