AJ12 -- KONIARIS RNA Sequencing

2026-11-03

THIS IS A SOURCES SOUGHT NOTICE ONLY . This is not a solicitation for bids , proposals , proposal abstracts , or quotations . The purpose of this Sources Sought Notice is to obtain information regarding the availability and capability of all qualified sources to perform a potential requirement . The responses received from interested contractors will assist the Government in determining the appropriate acquisition method . The Department of Veterans Affairs ( VA ), Network Contracting Office ( NCO ) 20 , is conducting market research to identify potential sources which can provide the following in support of the Portland VA Medical Center ( Portland VAMC ): Portland VAMC has a need for Transcriptomic ( RNA ) and epigenomic ( ATAC ) sequencing , STATEMENT OF WORK ( SOW ) 1 . Contract Title . Transcriptomic ( RNA ) and epigenomic ( ATAC ) sequencing 2 . Background . In order to understand mechanisms underpinning cachexia , it is necessary to generate transcriptomic and epigenomic profiles of samples that have undergone cachexia ( sepsis , cancer , liver regeneration ) with various pharmacological and genetic modifications . This study investigates mechanisms of the catabolic response to sepsis and the crosstalk between innate immune activation and organ homeostasis . Veterans are uniquely susceptible to sepsis as it is a major cause of death following trauma . Veterans will face a mortality rate from sepsis as high as 20 %, double that of the general population in the United States . Those who do survive sepsis may face long term weakness and cognitive dysfunction as well as increased risk of mortality for up to a year later . Understanding the molecular mechanisms behind the catabolic response to sepsis is critical to identify novel therapeutic targets to improve treatment for sepsis . This research is supporting the study Yap1 / TAZ and CD14 in the Catabolic Response to Sepsis by providing critical mechanistic insight into the role of Yap1 , TAZ , and CD14 in the catabolic response to sepsis . These sequencing studies will allow us to determine the genetic changes that occur when the above genes are manipulated in sepsis . 3 . Scope . The general scale of this contract will cover anywhere from 10 - 100 samples per year of transcriptomic ( RNA ) and epigenomic ( atac / methylome ) sequencing . It is requested that quantities are estimated only & that items are bulk ordered & does not exceed funding listed in IGCE . The vendor will provide a free courier so picks up samples for free . The samples are temperature sensitive and perishable so samples will be stored & shipped with dry ice provided by Koniaris lab . If samples are damaged , the lab will provide new undamaged samples . If samples are returned by vendor damaged , it will be at no cost to the lab to be corrected . 4 . Specific Tasks . Specific tasks may include : Task 1 ( optional ): Contractor may isolate RNA from tissues Task 2 : Contractor will perform quality control of RNA using a bioanalyzer , QuBit , or other method Task 3 : Contractor will perform library preparation of RNA Task 4 : Contractor will sequence RNA Task 5 ( optional ): Contractor may perform analysis including alignment to reference genome Task 6 ( optional ): Contractor may preform library preparation for ATAC sequencing Task 7 ( optional ): Contractor may sequence accessible genome Task 8 ( optional ) Contractor may analyze ATAC sequencing data including alignment to genome 5 . Performance Monitoring ( if applicable ). Dr . Adrian Baris will monitor samples prior to shipment to ensure they will meet the lab needs . Dr . Baris will also monitor results to ensure they are meeting the needs to the lab based on standard quality control parameters . 6 . Security Requirements . Contractor does not require background investigation & will not be accessing sensitive information PHI / PII nor will they be accessing sensitive lab areas unsupervised by VA hired personnel . 7 . Government - Furnished Equipment ( GFE )/ Government - Furnished Information ( GFI ). No GFE or GFI will be provided to the contractor 8 . Other Pertinent Information or Special Considerations . As we are handling delicate samples that should be in transit as little as possible , it is imperative that the facility performing the sequencing be as close to the site of initial processing ( Portland , OR ) as possible . a . Identification of Possible Follow - on Work . N / A b . Identification of Potential Conflicts of Interest ( COI ). N / A e . Inspection and Acceptance Criteria . Dr . Adrian Baris will monitor samples and results to ensure they meet lab needs and are undamaged . 9 . Risk Control I do not expect any safety issues . All samples will be free of infectious or hazardous materials . 10 . Place of Performance . Work will be performed at contractor size . Shipping of samples is included in pricing . 11 . Period of Performance . Base : 04 . 01 . 2026 03 . 31 . 2027 Option Year 1 : 04 . 01 . 2027 03 . 31 . 2028 Option Year 2 : 04 . 01 . 2028 03 . 31 . 2029 Option Year 3 : 04 . 01 . 2029 03 . 31 . 2030 12 . Delivery Schedule . N / A Potential candidates having the capabilities necessary to provide the above stated supplies at a fair and reasonable price are invited to respond to this Sources Sought Notice via e - mail to Nazanin Kreiner at nazanin . kreiner @ va . gov no later than February 19 , 2026 , 1 : 00PM Mountain Time . No telephone inquiries will be accepted . RESPONSES SHOULD INCLUDE THE FOLLOWING INFORMATION : Company name , address , SAM UEI , country where product is manufactured , and business size ; point of contact name , phone number , and e - mail address ; whether services are presently offered on a current GSA Federal Supply Schedule contract . NAICS Code 541715 Size Standard : 1 , 000 employees is applicable to determine business size standard . Any questions or concerns may also be directed via email to Nazanin Kreiner at nazanin . kreiner @ va . gov . Disclaimer and Important Notes : This Sources Sought Notice does not obligate the Government to award a contract or otherwise pay for the information provided in response . The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate . The Government will treat any information received as proprietary and will not share such information with other companies . Any organization responding to this Sources Sought Notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization ' s qualifications to perform the work . Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted . The Government may or may not issue a solicitation as a result of this announcement . There is no solicitation available at this time .

Oregon

2026-04-08