Identification of the Applicability Domain (in Terms of Toxicological Endpoints and Chemical Space) for the Use of Read-Across in Food Safety

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The aim of this procurement procedure is to qualify the applicability domain (in terms of toxicological endpoints and chemical space) for the use of RAx in food safety.Using pesticides as a model, the overall objective of the contract will be to extract chemical and toxicological information for active substances and their metabolites/degradation products (where available) from EFSA’s published conclusions on pesticides peer review and related assessment reports, and(i) test the applicability of the RAx approach for prediction of repeated dose toxicity; and(ii) identify supporting biological and toxicological information for in vivo and in vitro studies that will reduce uncertainty in the RAx.