Systematic review on the efficacy, effectiveness and safety of nasally administrated trivalent and quadrivalent A/Ann Arbor/6/1960-based live attenuated influenza vaccines (LAIV) in children and adolescents under the age of 18 years

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The objective of this assignment is to conduct a systematic literature review (SR) on the efficacy, effectiveness and safety of nasally administrated trivalent and quadrivalent A/Ann Arbor/6/1960-based live attenuated influenza vaccines (LAIV) in children and adolescents under the age of 18 years. The work will be performed by the contractor in collaboration with the ECDC Secretariat and a Working Group of subject-matter experts under the EU/EEA NITAG Collaboration network. These two bodies have drafted a protocol that will serve as instruction for the SR and that will be provided to the contractor. The SR will be published as a technical report on the ECDC website. The team conducting this project should have proven experience in the field of conducting systematic reviews on vaccines and immunisation practices according to the PRISMA guidelines (or equivalent) including literature search, meta-analysis, risk of bias assessment and the GRADE approach, preferably using cloud-based softwares. The duration of the project is estimated to be maximum 8 months. Maximum amount: 60, 000 EUROS.